Yet We Are Far From Affirming, That, Throughout The Whole Of The Eastern Part Of South America, From Porto Bello To Cayenne, Or From The Equator To The 10th Degree Of North Latitude Between The Meridians Of 54 And 71 Degrees, The Cinchona Absolutely Does Not Exist.

How can we be expected to know completely the flora of so vast an extent of country?

But, when we recollect, that even in Mexico no species of the genera cinchona and exostema has been discovered, either in the central table-land or in the plains, we are led to believe, that the mountainous islands of the West Indies and the Cordillera of the Andes have peculiar floras; and that they possess particular species of vegetation, which have neither passed from the islands to the continent, nor from South America to the coasts of New Spain.

It may be observed farther, that, when we reflect on the numerous analogies which exist between the properties of plants and their external forms, we are surprised to find qualities eminently febrifuge in the bark of trees belonging to different genera, and even different families.* (* It may be somewhat interesting to chemistry, physiology, and descriptive botany, to consider under the same point of view the plants which have been employed in intermittent fevers with different degrees of success. We find among rubiaceous plants, besides the cinchonas and exostemas, the Coutarea speciosa or Cayenne bark, the Portlandia grandiflora of the West Indies, another portlandia discovered by M. Sesse at Mexico, the Pinkneia pubescens of the United States, the berry of the coffee-tree, and perhaps the Macrocnemum corymbosum, and the Guettarda coccinea; among magnoliaceous plants, the tulip-tree and the Magnolia glauca; among zanthoxylaceous plants, the Cuspare of Angostura, known in America under the name of Orinoco bark, and the Zanthoxylon caribaeum; among leguminous plants, the geoffraeas, the Swietenia febrifuga, the Aeschynomene grandiflora, the Caesalpina bonducella; among caprifoliaceous plants, the Cornus florida and the Cuspa of Cumana; among rosaceous plants, the Cerasus virginiana and the Geum urbanum; among amentaceous plants, the willows, oaks, and birch-trees, of which the alcoholic tincture is used in Russia by the common people; the Populus tremuloides, etc.; among anonaceous plants, the Uvaria febrifuga, the fruit of which we saw administered with success in the Missions of Spanish Guiana; among simarubaceous plants, the Quassia amara, celebrated in the feverish plains of Surinam; among terebinthaceous plants, the Rhus glabrum; among euphorbiaceous plants, the Croton cascarilla; among composite plants, the Eupatorium perfoliatum, the febrifuge qualities of which are known to the savages of North America. Of the tulip-tree and the quassia, it is the bark of the roots that is used. Eminent febrifuge virtues have also been found in the cortical part of the roots of the Cinchona condaminea at Loxa; but it is fortunate, for the preservation of the species, that the roots of the real cinchona are not employed in pharmacy. Chemical researches are yet wanting upon the very powerful bitters contained in the roots of the Zanthoriza apiifolia, and the Actaea racemosa: the latter have sometimes been employed with success as a remedy against the epidemic yellow fever in New York.) Some of these barks so much resemble each other, that it is not easy to distinguish them at first sight. But before we examine the question, whether we shall one day discover, in the real cinchona, in the cuspa of Cumana, the Cortex Angosturae, the Indian swietenia, the willows of Europe, the berries of the coffee-tree and uvaria, a matter uniformly diffused, and exhibiting (like starch, caoutchouc, and camphor) the same chemical properties in different plants, we may ask whether, in the present state of physiology and medicine, a febrifuge principle ought to be admitted. Is it not probable, that the particular derangement in the organization, known under the vague name of the febrile state, and in which both the vascular and the nervous systems are at the same time attacked, yields to remedies which do not operate by the same principle, by the same mode of action on the same organs, by the same play of chemical and electrical attractions? We shall here confine ourselves to this observation, that, in the species of the genus cinchona, the antifebrile virtues do not appear to belong to the tannin (which is only accidentally mingled in them), or to the cinchonate of lime; but in a resiniform matter, soluble both by alcohol and by water, and which, it is believed, is composed of two principles, the cinchonic bitter and the cinchonic red.* (* In French, l'amer et le rouge cinchoniques.) May it then be admitted, that this resiniform matter, which possesses different degrees of energy according to the combinations by which it is modified, is found in all febrifuge substances? Those by which the sulphate of iron is precipitated of a green colour, like the real cinchona, the bark of the white willow, and the horned perisperm of the coffee-tree, do not on this account denote identity of chemical composition;* and that identity might even exist, without our concluding that the medical virtues were analogous. (* The cuspare bark (Cort. Angosturae) yields with iron a yellow precipitate; yet it is employed on the banks of the Orinoco, and particularly at the town of St. Thomas of Angostura, as an excellent cinchona; and on the other hand, the bark of the common cherry tree, which has scarcely any febrifuge quality, yields a green precipitate like the real cinchonas. Notwithstanding the extreme imperfection of vegetable chemistry, the experiments already made on cinchonas sufficiently show, that to judge of the febrifuge virtues of a bark, we must not attach too much importance either to the principle which turns to green the oxides of iron, or to the tannin, or to the matter which precipitates infusions of tan.) We see that specimens of sugar and tannin extracted from plants, not of the same family, present numerous differences: while the comparative analysis of sugar, gum, and starch; the discovery of the radical of the prussic acid (the effects of which are so powerful on the organization), and many other phenomena of vegetable chemistry, clearly prove that substances composed of identical elements, few in number and proportional in quantity, exhibit the most heterogeneous properties, on account of that particular mode of combination which corpuscular chemistry calls the arrangement of the particles.

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